what is diazepam used for Things To Know Before You Buy
what is diazepam used for Things To Know Before You Buy
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Fetal/Neonatal Adverse Reactions Benzodiazepines cross the placenta and may create respiratory depression, hypotonia and sedation in neonates. Watch neonates exposed to diazepam through pregnancy and labor for indications of sedation, respiratory depression, hypotonia, and feeding difficulties.
The risk of dependence improves with duration of treatment; It's also bigger in patients with a background of alcohol or drug abuse.
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Physical Dependence Diazepam tablets might develop Actual physical dependence from continued therapy. Physical dependence is a condition that develops because of physiological adaptation in response to repeated drug use, manifested by withdrawal signals and symptoms after abrupt discontinuation or maybe a significant dose reduction of a drug. Abrupt discontinuation or speedy dosage reduction of benzodiazepines or administration of flumazenil, a benzodiazepine antagonist, may well precipitate acute withdrawal reactions, which include seizures, which is usually life-threatening.
May perhaps damage an unborn baby. Usually do not use For anyone who is pregnant or may possibly become pregnant. If you employ diazepam through pregnancy, your baby could possibly be born with life-threatening withdrawal symptoms, and may need professional medical treatment for numerous weeks.
Dosage really should be individualized for maximum valuable effect. While the usual every day dosages specified underneath will satisfy the desires of most patients, there will be some who may perhaps need higher doses. In these types of instances dosage must be amplified cautiously to olanzapine vs diazepam stay away from adverse effects.
Taking VALIUM with particular other medicines could cause side effects or have an effect on how properly VALIUM or maybe the other medicines work. Do not start out or quit other medicines without speaking to your Health care company.
To lessen the chance of withdrawal reactions, use a gradual taper to discontinue Valium or lessen the dosage. If a patient develops withdrawal reactions, consider pausing the taper or escalating the dosage towards the earlier tapered dosage level.
This drugs should really come with a Medication Information and patient Guidelines. Read through and Stick to the Directions very carefully. Request your doctor When you've got any questions. Swallow the tablet total. Usually do not crush, break, or chew it. To make use of the oral solution:
Comprehensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has long been noted pursuing chronic administration of diazepam in balanced elderly male subjects. Metabolites of the drug are regarded to become considerably excreted with the kidney, and the risk of toxic reactions could be larger in patients with impaired renal function.
Diazepam is N-demethylated by CYP3A4 and 2C19 for the active metabolite N-desmethyldiazepam, which is hydroxylated by CYP3A4 to your Energetic metabolite temazepam. N-desmethyldiazepam and temazepam are equally even further metabolized to oxazepam. Temazepam and oxazepam are mostly eliminated by glucuronidation.
Abrupt withdrawal of diazepam in such scenarios might also be involved with a temporary rise in the frequency and/or severity of seizures.
Labor or Delivery Unique care must be taken when diazepam tablets are used for the duration of labor and supply, as high one doses might generate irregularities from the fetal heart rate and hypotonia, weak sucking, hypothermia, and moderate respiratory depression within the neonates.
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